Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes

GAD autoantibodies (GADAs) are sensitive markers of islet autoimmunity and type 1 diabetes. They form the basis of robust prediction models and are widely used for the recruitment of subjects at high risk of type 1 diabetes to prevention trials. However, GADAs are also found in many individuals at l...

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Publicado en:Diabetes
Autores principales: Williams, Alistair J.K., Lampasona, Vito, Schlosser, Michael, Mueller, Patricia W., Pittman, David L., Winter, William E., Akolkar, Beena, Wyatt, Rebecca, Brigatti, Cristina, Krause, Stephanie, Achenbach, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2015
Materias:
Immunology and Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542444/
https://ncbi.nlm.nih.gov/pubmed/25972570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1693
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