The Core Cysteines, (C909) of Islet Antigen-2 and (C945) of Islet Antigen-2β, Are Crucial to Autoantibody Binding in Type 1 Diabetes

Cysteines are thought integral to conformational epitopes of islet antigen-2 (IA-2) autoantibodies (IA-2A), possibly through disulfide bond formation. We therefore investigated which cysteines are critical to IA-2A binding in patients with newly diagnosed type 1 diabetes. All 10 cysteines in the int...

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Detalhes bibliográficos
Main Authors: Elvers, Karen T., Geoghegan, Ivey, Shoemark, Debbie K., Lampasona, Vito, Bingley, Polly J., Williams, Alistair J.K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526053/
https://ncbi.nlm.nih.gov/pubmed/22966073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1590
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