Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of HIV-1 Virions and Provirus-Activated Latently Infected Cells

Both HIV-1 virions and infected cells use their surface regulators of complement activation (RCA) to resist antibody-dependent complement-mediated lysis (ADCML). Blockage of the biological function of RCA members, particularly CD59 (a key RCA member that controls formation of the membrane attack com...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Yang, Kai, Lan, Jie, Shepherd, Nicole, Hu, Ningjie, Xing, Yanyan, Byrd, Daniel, Amet, Tohti, Jewell, Corlin, Gupta, Samir, Kounga, Carole, Gao, Jimin, Yu, Qigui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542366/
https://ncbi.nlm.nih.gov/pubmed/26136568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01614-15
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