Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences.

A new chimeric oncogene, trk-2h, has been generated by recombination of two segments of MDA-MB231 human breast carcinoma cell line DNA after transfection in NIH/3T3 cells. The rearranged DNA segments form a fused transcriptional unit. Sequences at the 3' end are homologous to the tyrosine kinas...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Kozma, S C, Redmond, S M, Fu, X C, Saurer, S M, Groner, B, Hynes, N E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454232/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2966065/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb02794.x
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