טוען...
Single-molecule enzymology of RNA: Essential functional groups impact catalysis from a distance
The hairpin ribozyme is a minimalist paradigm for studying RNA folding and function. In this enzyme, two domains dock by induced fit to form a catalytic core that mediates a specific backbone cleavage reaction. Here, we have fully dissected its reversible reaction pathway, which comprises two struct...
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| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2004
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC454165/ https://ncbi.nlm.nih.gov/pubmed/15218105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403575101 |
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