Rapid Glucocorticoid Feedback Inhibition of ACTH Secretion Involves Ligand-Dependent Membrane Association of Glucocorticoid Receptors

The hypothesis that rapid glucocorticoid inhibition of pituitary ACTH secretion mediates a feedforward/feedback mechanism responsible for the hourly glucocorticoid pulsatility was tested in cultured pituitary cells. Perifusion with 30 pM CRH caused sustained the elevation of ACTH secretion. Superimp...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Deng, Qiong, Riquelme, Denise, Trinh, Loc, Low, Malcolm J., Tomić, Melanija, Stojilkovic, Stanko, Aguilera, Greti
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541620/
https://ncbi.nlm.nih.gov/pubmed/26121342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/EN.2015-1265
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