Coupling of retinal isomerization to the activation of rhodopsin

Activation of the visual pigment rhodopsin is caused by 11-cis to -trans isomerization of its retinal chromophore. High-resolution solid-state NMR measurements on both rhodopsin and the metarhodopsin II intermediate show how retinal isomerization disrupts helix interactions that lock the receptor of...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Patel, Ashish B., Crocker, Evan, Eilers, Markus, Hirshfeld, Amiram, Sheves, Mordechai, Smith, Steven O.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454162/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15220479/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402848101
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