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The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration

RPE65 is essential in the operation of the visual cycle and functions as a chaperone for all-trans-retinyl esters, the substrates for isomerization in the visual cycle. RPE65 stereospecifically binds all-trans-retinyl esters with a K(D) of 47 nM. It is shown here by using a quantitative fluorescence...

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Detalhes bibliográficos
Main Authors: Gollapalli, Deviprasad R., Rando, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC454159/
https://ncbi.nlm.nih.gov/pubmed/15218101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401936101
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