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Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways

In the Escherichia coli periplasm, the formation of protein disulfide bonds is catalyzed by DsbA and DsbC. DsbA is a monomer that is maintained in a fully oxidized state by the membrane enzyme DsbB, whereas DsbC is a dimer that is kept reduced by a second membrane protein, DsbD. Although the catalyt...

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Главные авторы: Segatori, Laura, Paukstelis, Paul J., Gilbert, Hiram F., Georgiou, George
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC454158/
https://ncbi.nlm.nih.gov/pubmed/15220477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403003101
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