Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

Mammalian cardiomyocytes become post-mitotic shortly after birth. Understanding how this occurs is highly relevant to cardiac regenerative therapy. Yet, how cardiomyocytes achieve and maintain a post-mitotic state is unknown. Here, we show that cardiomyocyte centrosome integrity is lost shortly afte...

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Pubblicato in:eLife
Autori principali: Zebrowski, David C, Vergarajauregui, Silvia, Wu, Chi-Chung, Piatkowski, Tanja, Becker, Robert, Leone, Marina, Hirth, Sofia, Ricciardi, Filomena, Falk, Nathalie, Giessl, Andreas, Just, Steffen, Braun, Thomas, Weidinger, Gilbert, Engel, Felix B
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2015
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541494/
https://ncbi.nlm.nih.gov/pubmed/26247711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05563
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