Structural Basis for Mitotic Centrosome Assembly in Flies

In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold is unclear. We show that scaffold assembly requires conserved leucine zipper (LZ) and Cnn-motif 2 (CM2) domains that co-assemble into a 2:2 c...

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Publicat a:Cell
Autors principals: Feng, Zhe, Caballe, Anna, Wainman, Alan, Johnson, Steven, Haensele, Andreas F.M., Cottee, Matthew A., Conduit, Paul T., Lea, Susan M., Raff, Jordan W.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457487/
https://ncbi.nlm.nih.gov/pubmed/28575671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.05.030
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