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Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury

Acute lung injury (ALI) during sepsis is characterized by bilateral alveolar infiltrates, lung edema and respiratory failure. Here, we examined the efficacy the DNA methyl transferase (DNMT) inhibitor 5-Aza 2-deoxycytidine (Aza), the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA), as well...

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書誌詳細
出版年:J Cell Sci
主要な著者: Thangavel, Jayakumar, Samanta, Saheli, Rajasingh, Sheeja, Barani, Bahar, Xuan, Yu-Ting, Dawn, Buddhadeb, Rajasingh, Johnson
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541045/
https://ncbi.nlm.nih.gov/pubmed/26116574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.170258
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