Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury

Acute lung injury (ALI) during sepsis is characterized by bilateral alveolar infiltrates, lung edema and respiratory failure. Here, we examined the efficacy the DNA methyl transferase (DNMT) inhibitor 5-Aza 2-deoxycytidine (Aza), the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA), as well...

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Veröffentlicht in:J Cell Sci
Hauptverfasser: Thangavel, Jayakumar, Samanta, Saheli, Rajasingh, Sheeja, Barani, Bahar, Xuan, Yu-Ting, Dawn, Buddhadeb, Rajasingh, Johnson
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541045/
https://ncbi.nlm.nih.gov/pubmed/26116574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.170258
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