Identification of Lineage-Specific Cis-Regulatory Modules Associated with Variation in Transcription Factor Binding and Chromatin Activity Using Ornstein–Uhlenbeck Models

Scoring the impact of noncoding variation on the function of cis-regulatory regions, on their chromatin state, and on the qualitative and quantitative expression levels of target genes is a fundamental problem in evolutionary genomics. A particular challenge is how to model the divergence of quantit...

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Bibliographic Details
Published in:Mol Biol Evol
Main Authors: Naval-Sánchez, Marina, Potier, Delphine, Hulselmans, Gert, Christiaens, Valerie, Aerts, Stein
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Methods
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540964/
https://ncbi.nlm.nih.gov/pubmed/25944915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msv107
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