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Substrate spectrum of human excinuclease: repair of abasic sites, methylated bases, mismatches, and bulky adducts.

Nucleotide-excision repair is the repair system for removing bulky lesions from DNA. Humans deficient in this repair pathway suffer from xeroderma pigmentosum (XP), a disease characterized by photodermatoses, including skin cancers. At the cellular level, XP patients fail to remove cyclobutane pyrim...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Huang, J C, Hsu, D S, Kazantsev, A, Sancar, A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45407/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991608/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12213
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