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Tricyclic analogues of epidithiodioxopiperazine alkaloids with promising in vitro and in vivo antitumor activity

Epipolythiodioxopiperazine (ETP) alkaloids are structurally elaborate alkaloids that show potent antitumor activity. However, their high toxicity and demonstrated interactions with various biological receptors compromises their therapeutic potential. In an effort to mitigate these disadvantages, a s...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: Baumann, Marcus, Dieskau, André P., Loertscher, Brad M., Walton, Mary C., Nam, Sangkil, Xie, Jun, Horne, David, Overman, Larry E.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540405/
https://ncbi.nlm.nih.gov/pubmed/26301062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01536g
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