TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic...

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Библиографические подробности
Опубликовано в: :J Cell Biol
Главные авторы: Pedersen, Rune Troelsgaard, Kruse, Thomas, Nilsson, Jakob, Oestergaard, Vibe H., Lisby, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2015
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539992/
https://ncbi.nlm.nih.gov/pubmed/26283799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502107
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