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TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells
Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic...
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| Foilsithe in: | J Cell Biol |
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| Main Authors: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
The Rockefeller University Press
2015
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539992/ https://ncbi.nlm.nih.gov/pubmed/26283799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502107 |
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