TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Pedersen, Rune Troelsgaard, Kruse, Thomas, Nilsson, Jakob, Oestergaard, Vibe H., Lisby, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2015
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539992/
https://ncbi.nlm.nih.gov/pubmed/26283799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201502107
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