The A581G Mutation in the Gene Encoding Plasmodium falciparum Dihydropteroate Synthetase Reduces the Effectiveness of Sulfadoxine-Pyrimethamine Preventive Therapy in Malawian Pregnant Women

Background. The A581G mutation in the gene encoding Plasmodium falciparum dihydropteroate synthase (dhps), in combination with the quintuple mutant involving mutations in both dhps and the gene encoding dihydrofolate reductase (dhfr), the so-called sextuple mutant, has been associated with increased...

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Bibliografiske detaljer
Udgivet i:J Infect Dis
Main Authors: Gutman, Julie, Kalilani, Linda, Taylor, Steve, Zhou, Zhiyong, Wiegand, Ryan E., Thwai, Kyaw L., Mwandama, Dyson, Khairallah, Carole, Madanitsa, Mwayi, Chaluluka, Ebbie, Dzinjalamala, Fraction, Ali, Doreen, Mathanga, Don P., Skarbinski, Jacek, Shi, Ya Ping, Meshnick, Steve, ter Kuile, Feiko O.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539907/
https://ncbi.nlm.nih.gov/pubmed/25564249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu836
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