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Maintaining Tumour Heterogeneity in Patient-Derived Tumour Xenografts

Pre-clinical models often fail to capture the diverse heterogeneity of human malignancies and as such lack clinical predictive power. Patient-derived tumour xenografts (PDXs) have emerged as a powerful technology: capable of retaining the molecular heterogeneity of their originating sample. However,...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Cassidy, John W, Caldas, Carlos, Bruna, Alejandra
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539570/
https://ncbi.nlm.nih.gov/pubmed/26180079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0727
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