Optogenetic activation of intracellular adenosine A(2A) receptor signaling in hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer’s disease through the antagonism of adenosine A(2A) receptors (A(2A)R). To test if A(2A)R activation in hippocampus is actually sufficient to impair memory function and to beg...

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Vydáno v:Mol Psychiatry
Hlavní autoři: Li, Ping, Rial, Daniel, Canas, Paula M., Yoo, Ji-Hoon, Li, Wei, Zhou, Xiangtian, Wang, Yumei, van Westen, Gerard J.P., Payen, Marie-Pierre, Augusto, Elisabete, Gonçalves, Nélio, Tomé, Angelo R., Li, Zhihui, Wu, Zhongnan, Hou, Xianhua, Zhou, Yuanguo, IJzerman, Ad P., Boyden, Edward S., Cunha, Rodrigo A., Qu, Jia, Chen, Jiang-Fan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539301/
https://ncbi.nlm.nih.gov/pubmed/25687775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2014.182
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