Optogenetic activation of intracellular adenosine A(2A) receptor signaling in hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer’s disease through the antagonism of adenosine A(2A) receptors (A(2A)R). To test if A(2A)R activation in hippocampus is actually sufficient to impair memory function and to beg...

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Publicado no:Mol Psychiatry
Main Authors: Li, Ping, Rial, Daniel, Canas, Paula M., Yoo, Ji-Hoon, Li, Wei, Zhou, Xiangtian, Wang, Yumei, van Westen, Gerard J.P., Payen, Marie-Pierre, Augusto, Elisabete, Gonçalves, Nélio, Tomé, Angelo R., Li, Zhihui, Wu, Zhongnan, Hou, Xianhua, Zhou, Yuanguo, IJzerman, Ad P., Boyden, Edward S., Cunha, Rodrigo A., Qu, Jia, Chen, Jiang-Fan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539301/
https://ncbi.nlm.nih.gov/pubmed/25687775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2014.182
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