Characterizing Methyl-Bearing Side Chain Contacts and Dynamics Mediating Amyloid β Protofibril Interactions Using (13)C(methyl)-DEST and Lifetime Line Broadening()

Many details pertaining to the formation and interactions of protein aggregates associated with neurodegenerative diseases are invisible to conventional biophysical techniques. We recently introduced (15)N dark-state exchange saturation transfer (DEST) and (15)N lifetime line-broadening to study sol...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Fawzi, Nicolas L., Libich, David S., Ying, Jinfa, Tugarinov, Vitali, Clore, G. Marius
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539159/
https://ncbi.nlm.nih.gov/pubmed/25130489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201405180
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