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Viral Nucleases Induce an mRNA Degradation-Transcription Feedback Loop in Mammalian Cells
Gamma-herpesviruses encode a cytoplasmic mRNA-targeting endonuclease, SOX, that cleaves most cellular mRNAs. Cleaved fragments are subsequently degraded by the cellular 5′-3′ mRNA exonuclease Xrn1, thereby suppressing cellular gene expression and facilitating viral evasion of host defenses. We revea...
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| Veröffentlicht in: | Cell Host Microbe |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier Inc.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538998/ https://ncbi.nlm.nih.gov/pubmed/26211836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.06.019 |
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