Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential

Phase II metabolism is prominently governed by UDP-glucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study determined the...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Margaillan, Guillaume, Rouleau, Michèle, Klein, Kathrin, Fallon, John K., Caron, Patrick, Villeneuve, Lyne, Smith, Philip C., Zanger, Ulrich M., Guillemette, Chantal
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2015
Schlagworte:
Short Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538857/
https://ncbi.nlm.nih.gov/pubmed/26076694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065391
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