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Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential
Phase II metabolism is prominently governed by UDP-glucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study determined the...
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Publié dans: | Drug Metab Dispos |
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Auteurs principaux: | , , , , , , , , |
Format: | Artigo |
Langue: | Inglês |
Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538857/ https://ncbi.nlm.nih.gov/pubmed/26076694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065391 |
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