Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential

Phase II metabolism is prominently governed by UDP-glucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study determined the...

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Detalles Bibliográficos
Publicado en:Drug Metab Dispos
Autores principales: Margaillan, Guillaume, Rouleau, Michèle, Klein, Kathrin, Fallon, John K., Caron, Patrick, Villeneuve, Lyne, Smith, Philip C., Zanger, Ulrich M., Guillemette, Chantal
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2015
Materias:
Short Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538857/
https://ncbi.nlm.nih.gov/pubmed/26076694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065391
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