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Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin

Brain-derived neurotrophic factor (BDNF) is known to modulate synapse development and plasticity, but the source of synaptic BDNF and molecular mechanisms regulating BDNF release remain unclear. Using exogenous BDNF tagged with quantum dots (BDNF-QDs), we found that endocytosed BDNF-QDs were prefere...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wong, Yu-Hui, Lee, Chia-Ming, Xie, Wenjun, Cui, Bianxiao, Poo, Mu-ming
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538679/
https://ncbi.nlm.nih.gov/pubmed/26216953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1511830112
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