AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer

To improve ovarian cancer patient survival, effective treatments addressing chemoresistant recurrences are particularly needed. Mullerian inhibiting substance (MIS) has been shown to inhibit the growth of a stem-like population of ovarian cancer cells. We have recently engineered peptide modificatio...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Pépin, David, Sosulski, Amanda, Zhang, Lihua, Wang, Dan, Vathipadiekal, Vinod, Hendren, Katherine, Coletti, Caroline M., Yu, Aaron, Castro, Cesar M., Birrer, Michael J., Gao, Guangping, Donahoe, Patricia K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538667/
https://ncbi.nlm.nih.gov/pubmed/26216943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510604112
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