AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer

To improve ovarian cancer patient survival, effective treatments addressing chemoresistant recurrences are particularly needed. Mullerian inhibiting substance (MIS) has been shown to inhibit the growth of a stem-like population of ovarian cancer cells. We have recently engineered peptide modificatio...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pépin, David, Sosulski, Amanda, Zhang, Lihua, Wang, Dan, Vathipadiekal, Vinod, Hendren, Katherine, Coletti, Caroline M., Yu, Aaron, Castro, Cesar M., Birrer, Michael J., Gao, Guangping, Donahoe, Patricia K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538667/
https://ncbi.nlm.nih.gov/pubmed/26216943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510604112
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