Alkaloids as Inhibitors of Malate Synthase from Paracoccidioides spp.: Receptor-Ligand Interaction-Based Virtual Screening and Molecular Docking Studies, Antifungal Activity, and the Adhesion Process

Paracoccidioides is the agent of paracoccidioidomycosis. Malate synthase plays a crucial role in the pathogenicity and virulence of various fungi, such as those that are human pathogens. Thus, an inhibitor of this enzyme may be used as a powerful antifungal without side effects in patients once thes...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Costa, Fausto Guimaraes, Neto, Benedito Rodrigues da Silva, Gonçalves, Ricardo Lemes, da Silva, Roosevelt Alves, de Oliveira, Cecília Maria Alves, Kato, Lucília, Freitas, Carla dos Santos, Giannini, Maria José Soares Mendes, da Silva, Julhiany de Fátima, Soares, Célia Maria de Almeida, Pereira, Maristela
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Chemistry; Biosynthesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538557/
https://ncbi.nlm.nih.gov/pubmed/26124176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04711-14
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