Alkaloids as Inhibitors of Malate Synthase from Paracoccidioides spp.: Receptor-Ligand Interaction-Based Virtual Screening and Molecular Docking Studies, Antifungal Activity, and the Adhesion Process

Paracoccidioides is the agent of paracoccidioidomycosis. Malate synthase plays a crucial role in the pathogenicity and virulence of various fungi, such as those that are human pathogens. Thus, an inhibitor of this enzyme may be used as a powerful antifungal without side effects in patients once thes...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Costa, Fausto Guimaraes, Neto, Benedito Rodrigues da Silva, Gonçalves, Ricardo Lemes, da Silva, Roosevelt Alves, de Oliveira, Cecília Maria Alves, Kato, Lucília, Freitas, Carla dos Santos, Giannini, Maria José Soares Mendes, da Silva, Julhiany de Fátima, Soares, Célia Maria de Almeida, Pereira, Maristela
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Chemistry; Biosynthesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538557/
https://ncbi.nlm.nih.gov/pubmed/26124176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04711-14
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