Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010)

Fungal infections have increased dramatically in the last 2 decades, and fighting infectious diseases requires innovative approaches such as the combination of two drugs acting on different targets or even targeting a salvage pathway of one of the drugs. The fungal cell wall biosynthesis is inhibite...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Valiante, Vito, Monteiro, Maria Cândida, Martín, Jesús, Altwasser, Robert, El Aouad, Noureddine, González, Ignacio, Kniemeyer, Olaf, Mellado, Emilia, Palomo, Sara, de Pedro, Nuria, Pérez-Victoria, Ignacio, Tormo, José R., Vicente, Francisca, Reyes, Fernando, Genilloud, Olga, Brakhage, Axel A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538548/
https://ncbi.nlm.nih.gov/pubmed/26055366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00683-15
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