Llwytho...

Reprioritizing Genetic Associations in Hit Regions Using LASSO-Based Resample Model Averaging

Significance testing one SNP at a time has proven useful for identifying genomic regions that harbor variants affecting human disease. But after an initial genome scan has identified a “hit region” of association, single-locus approaches can falter. Local linkage disequilibrium (LD) can make both th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Valdar, William, Sabourin, Jeremy, Nobel, Andrew, Holmes, Christopher C
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470705/
https://ncbi.nlm.nih.gov/pubmed/22549815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21639
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