Determination of Bedaquiline in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry

Bedaquiline, a diarylquinoline for the treatment of multidrug-resistant tuberculosis (TB), relies on exposure-dependent killing. As data on drug exposure in specific populations are scarce, pharmacokinetic studies may be of interest. No simple and robust validated liquid chromatography-tandem mass s...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Alffenaar, Jan-Willem C., Bolhuis, Mathieu, van Hateren, Kai, Sturkenboom, Marieke, Akkerman, Onno, de Lange, Wiel, Greijdanus, Ben, van der Werf, Tjip, Touw, Daan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Analytical Procedures
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538542/
https://ncbi.nlm.nih.gov/pubmed/26149993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00276-15
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