In Silico-Based High-Throughput Screen for Discovery of Novel Combinations for Tuberculosis Treatment

There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordinary differential equations (ODE), we constructed an...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Singh, Ragini, Ramachandran, Vasanthi, Shandil, Radha, Sharma, Sreevalli, Khandelwal, Swati, Karmarkar, Malancha, Kumar, Naveen, Solapure, Suresh, Saralaya, Ramanatha, Nanduri, Robert, Panduga, Vijender, Reddy, Jitendar, Prabhakar, K. R., Rajagopalan, Swaminathan, Rao, Narasimha, Narayanan, Shridhar, Anandkumar, Anand, Balasubramanian, V., Datta, Santanu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538536/
https://ncbi.nlm.nih.gov/pubmed/26149995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05148-14
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