Telavancin Demonstrates Activity against Methicillin-Resistant Staphylococcus aureus Isolates with Reduced Susceptibility to Vancomycin, Daptomycin, and Linezolid in Broth Microdilution MIC and One-Compartment Pharmacokinetic/Pharmacodynamic Models

Methicillin-resistant Staphylococcus aureus (MRSA) isolates have arisen with reduced susceptibility to several anti-MRSA agents. Telavancin (TLV), a novel anti-MRSA agent, retains low MICs against these organisms. Our objective was to determine the MICs for TLV, daptomycin (DAP), vancomycin (VAN), a...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Smith, Jordan R., Barber, Katie E., Hallesy, Jessica, Raut, Animesh, Rybak, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538535/
https://ncbi.nlm.nih.gov/pubmed/26124162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00773-15
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