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Mycobacterium tuberculosis Folate Metabolism and the Mechanistic Basis for para-Aminosalicylic Acid Susceptibility and Resistance

para-Aminosalicylic acid (PAS) entered clinical use in 1946 as the second exclusive drug for the treatment of tuberculosis (TB). While PAS was initially a first-line TB drug, the introduction of more potent antitubercular agents relegated PAS to the second-line tier of agents used for the treatment...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Minato, Yusuke, Thiede, Joshua M., Kordus, Shannon Lynn, McKlveen, Edward J., Turman, Breanna J., Baughn, Anthony D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538520/
https://ncbi.nlm.nih.gov/pubmed/26033719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00647-15
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