Mutation Landscape of Acquired Cross-Resistance to Glycopeptide and β-Lactam Antibiotics in Enterococcus faecium

Bypass of the d,d-transpeptidase activity of penicillin-binding proteins by an l,d-transpeptidase (Ldt(fm)) results in resistance to ampicillin and glycopeptides in Enterococcus faecium M9, a mutant obtained by nine consecutive selection steps. Resistance requires activation of a cryptic locus for p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Sacco, Emmanuelle, Cortes, Mélanie, Josseaume, Nathalie, Bouchier, Christiane, Dubée, Vincent, Hugonnet, Jean-Emmanuel, Mainardi, Jean-Luc, Rice, Louis B., Arthur, Michel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538475/
https://ncbi.nlm.nih.gov/pubmed/26077262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00634-15
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