Population Approach To Analyze the Pharmacokinetics of Free and Total Lopinavir in HIV-Infected Pregnant Women and Consequences for Dose Adjustment

The aims of this study were to describe the unbound and total lopinavir (LPV) pharmacokinetics in pregnant women in order to evaluate if a dosing adjustment is necessary during pregnancy. Lopinavir placental transfer is described, and several genetic covariates were tested to explain its variability...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Fauchet, Floris, Treluyer, Jean-Marc, Illamola, Silvia M., Pressiat, Claire, Lui, Gabrielle, Valade, Elodie, Mandelbrot, Laurent, Lechedanec, Jerome, Delmas, Sandrine, Blanche, Stéphane, Warszawski, Josiane, Urien, Saik, Tubiana, Roland, Hirt, Déborah
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538471/
https://ncbi.nlm.nih.gov/pubmed/26149996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00863-15
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge