Discovery of Novel Isatin-Based p53 Inducers

[Image: see text] A series of isatin Schiff base derivatives were identified during in silico screening of the small molecule library for novel activators of p53. The compounds selected based on molecular docking results were further validated by a high-content screening assay using U2OS human osteo...

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Publicado en:ACS Med Chem Lett
Main Authors: Davidovich, P., Aksenova, V., Petrova, V., Tentler, D., Orlova, D., Smirnov, S., Gurzhiy, V., Okorokov, A. L., Garabadzhiu, A., Melino, G., Barlev, N., Tribulovich, V.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538431/
https://ncbi.nlm.nih.gov/pubmed/26288684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00011
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