Discovery of Novel Isatin-Based p53 Inducers

[Image: see text] A series of isatin Schiff base derivatives were identified during in silico screening of the small molecule library for novel activators of p53. The compounds selected based on molecular docking results were further validated by a high-content screening assay using U2OS human osteo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Davidovich, P., Aksenova, V., Petrova, V., Tentler, D., Orlova, D., Smirnov, S., Gurzhiy, V., Okorokov, A. L., Garabadzhiu, A., Melino, G., Barlev, N., Tribulovich, V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2015
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538431/
https://ncbi.nlm.nih.gov/pubmed/26288684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00011
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