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Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms
[Image: see text] Systematic halogenation of two native opioid peptides has shown that halogen atoms can modulate peptide–receptor interactions in different manners. First, halogens may produce a steric hindrance that reduces the binding of the peptide to the receptor. Second, chlorine, bromine, or...
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Publicado no: | ACS Med Chem Lett |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Chemical
Society
2015
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538429/ https://ncbi.nlm.nih.gov/pubmed/26288687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00126 |
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