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Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms

[Image: see text] Systematic halogenation of two native opioid peptides has shown that halogen atoms can modulate peptide–receptor interactions in different manners. First, halogens may produce a steric hindrance that reduces the binding of the peptide to the receptor. Second, chlorine, bromine, or...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Rosa, Mònica, Caltabiano, Gianluigi, Barreto-Valer, Katy, Gonzalez-Nunez, Verónica, Gómez-Tamayo, José C., Ardá, Ana, Jiménez-Barbero, Jesús, Pardo, Leonardo, Rodríguez, Raquel E., Arsequell, Gemma, Valencia, Gregorio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538429/
https://ncbi.nlm.nih.gov/pubmed/26288687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00126
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