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Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells

Cell lines have been used for drug discovery as useful models of cancers; however, they do not recapitulate cancers faithfully, especially in the points of rapid growth rate and microenvironment independency. Consequently, the majority of conventional anti-cancer drugs are less sensitive to slow gro...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Sugimoto, Keiki, Hayakawa, Fumihiko, Shimada, Satoko, Morishita, Takanobu, Shimada, Kazuyuki, Katakai, Tomoya, Tomita, Akihiro, Kiyoi, Hitoshi, Naoe, Tomoki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538400/
https://ncbi.nlm.nih.gov/pubmed/26278963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13054
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