The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice

RATIONALE: Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice. OBJECTIVE: We test the ability of GSK1521498 to reduce alcohol consumption...

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Publicat a:Psychopharmacology (Berl)
Autors principals: Ripley, Tamzin L., Sanchez-Roige, Sandra, Bullmore, Edward T., Mugnaini, Manolo, Maltby, Kay, Miller, Sam R., Wille, David R., Nathan, Pradeep, Stephens, David N.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2015
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537503/
https://ncbi.nlm.nih.gov/pubmed/26141191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-015-3995-x
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