Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro

BACKGROUND: The tumor microenvironment is characterized by regions of hypoxia and acidosis which are linked to poor prognosis. This occurs due to an aberrant vasculature as well as high rates of glycolysis and lactate production in tumor cells even in the presence of oxygen (the Warburg effect), whi...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Sørensen, Brita Singers, Busk, Morten, Overgaard, Jens, Horsman, Michael R., Alsner, Jan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537201/
https://ncbi.nlm.nih.gov/pubmed/26274822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134955
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