In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors

BACKGROUND: Tumor hypoxia is linked to poor prognosis, but identification and quantification of tissue hypoxia remains a challenge. The hypoxia-specificity of HIF-1α target genes in vivo has been questioned due to the confounding influence of other microenvironmental abnormalities known to affect ge...

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Bibliographic Details
Main Authors: Busk, Morten, Toustrup, Kasper, Sørensen, Brita S, Alsner, Jan, Horsman, Michael R, Jakobsen, Steen, Overgaard, Jens
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042974/
https://ncbi.nlm.nih.gov/pubmed/21306648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-63
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