A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer

A functional rs4245739 A>C single nucleotide polymorphism (SNP) locating in the MDM43’-untranslated (3’-UTR) region creates a miR-191-5p or miR-887-3p targeting sites. This change results in decreased expression of oncogene MDM4. Therefore, we examined the association between this SNP and small c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gao, Feng, Xiong, Xiangyu, Pan, Wenting, Yang, Xinyu, Zhou, Changchun, Yuan, Qipeng, Zhou, Liqing, Yang, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537101/
https://ncbi.nlm.nih.gov/pubmed/26274820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135647
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