A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Herein, we evaluated the anti-cancer effect and molecular mechanisms of a novel betulinic acid (BA) derivative, SYK023, by using two mouse models of lung cancer driven by Kras(G12D) or EGFR(L858R). We found that SYK023 inhibits lung tumor proliferation, without side effects in vivo or cytotoxicity i...

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Publicat a:Oncotarget
Autors principals: Hsu, Tsung-I, Chen, Ying-Jung, Hung, Chia-Yang, Wang, Yi-Chang, Lin, Sin-Jin, Su, Wu-Chou, Lai, Ming-Derg, Kim, Sang-Yong, Wang, Qiang, Qian, Keduo, Goto, Masuo, Zhao, Yu, Kashiwada, Yoshiki, Lee, Kuo-Hsiung, Chang, Wen-Chang, Hung, Jan-Jong
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537041/
https://ncbi.nlm.nih.gov/pubmed/25909174
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