Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma

Human multiple myeloma (MM) is characterized by accumulation of malignant terminally differentiated plasma cells (PCs) in the bone marrow (BM), raising the question when during maturation neoplastic transformation begins. Immunoglobulin IGHV genes carry imprints of clonal tumor history, delineating...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cowan, Graeme, Weston-Bell, Nicola J., Bryant, Dean, Seckinger, Anja, Hose, Dirk, Zojer, Niklas, Sahota, Surinder S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537010/
https://ncbi.nlm.nih.gov/pubmed/25929340
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