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Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma
BACKGROUND: Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. The constitutive expression of HIF-1α in MM suggests that inhibition of HIF-1α-mediated transcription represents an interesting target in MM. METHODS: As p300 is a crucial co-activator of hypoxia-inducible transcription...
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| Publicado no: | Br J Cancer |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4782210/ https://ncbi.nlm.nih.gov/pubmed/26867162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.20 |
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