Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma

BACKGROUND: Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. The constitutive expression of HIF-1α in MM suggests that inhibition of HIF-1α-mediated transcription represents an interesting target in MM. METHODS: As p300 is a crucial co-activator of hypoxia-inducible transcription...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Viziteu, Elena, Grandmougin, Camille, Goldschmidt, Hartmut, Seckinger, Anja, Hose, Dirk, Klein, Bernard, Moreaux, Jerome
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782210/
https://ncbi.nlm.nih.gov/pubmed/26867162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.20
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