Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.

The type II DNA topoisomerases are targets for a variety of chemotherapeutic agents, including the antibacterial quinolones and several families of antitumor drugs. These agents stabilize an enzyme-DNA cleavage complex that consists of the topoisomerase covalently linked to the 5' phosphates of a do...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Howard, M T, Neece, S H, Matson, S W, Kreuzer, K N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45370/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991579/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12031
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